p130 Monoclonal Antibody (130P215 (DCS-215)), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA514305

Catalog No. PIMA514305

Description

MA5-14305 targets p130/Rb2 in IF, IHC (P), IP, and WB applications and shows reactivity with Human and Rat samples. The MA5-14305 immunogen is a synthetic peptide from p130 corresponding to aa878-913.

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.

Specifications

• Antigen: p130
• Classification: Monoclonal
• Concentration: 0.4 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q08999
• Gene Symbols: RBL2
• Immunogen: A synthetic peptide from p130 corresponding to aa878-913
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 130P215 (DCS-215)
• Conjugate: Unconjugated
• Gene: RBL2
• Gene Alias: 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RB transcriptional corepressor like 2; Rb2; rb2 p130; Rbl2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related protein 2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 5934
• Content And Storage: 4° C
• Form: Liquid