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p130 Monoclonal Antibody (130P215 (DCS-215)), Invitrogen™

Catalog No. PIMA514305
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500 μL
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Catalog No. Quantity
PIMA514305 500 μL
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Catalog No. PIMA514305 Supplier Thermo Scientific Supplier No. MA514305

Description

Mouse Monoclonal Antibody

MA5-14305 targets p130/Rb2 in IF, IHC (P), IP, and WB applications and shows reactivity with Human and Rat samples. The MA5-14305 immunogen is a synthetic peptide from p130 corresponding to aa878-913.

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p130
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 130P215 (DCS-215)
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene RBL2
Gene Accession No. Q08999
Gene Alias 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RB transcriptional corepressor like 2; Rb2; rb2 p130; Rbl2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gene Symbols RBL2
Host Species Mouse
Immunogen A synthetic peptide from p130 corresponding to aa878-913
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5934
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1
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