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Invitrogen™ p130 Monoclonal Antibody (KAB40)
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Catalog No. 01674288
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100 μg
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Catalog No. Quantity
01-674-288 100 μg
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Catalog No. 01-674-288 Supplier Invitrogen™ Supplier No. MA112364
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Description

Mouse Monoclonal Antibody

This antibody recognizes both the phosphorylated or unphosphorylated forms of p130 at a MW of 130kDa. It is suitable for use in Western blot with His-tagged or GST-tagged proteins.

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p130
Applications Western Blot
Classification Monoclonal
Clone KAB40
Conjugate Unconjugated
Formulation PBS with 0.08% sodium azide
Gene RBL2
Gene Accession No. O55081, Q08999, Q64700
Gene Alias 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RB transcriptional corepressor like 2; Rb2; rb2 p130; Rbl2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gene Symbols RBL2
Host Species Mouse
Immunogen GST fusion protein to the N terminus of p130.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19651, 5934, 81758
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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