Invitrogen™ p130 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA132114

Catalog No. PIPA132114

Description

Store as a concentrated solution. Centrifuge briefly prior to opening vial.

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.

Specifications

• Antigen: p130
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RBL2
• Gene Alias: 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RB transcriptional corepressor like 2; Rb2; rb2 p130; Rbl2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related protein 2
• Host Species: Rabbit
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: Conc. Not Determined
• Formulation: Whole serum, 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene Accession No.: O55081, Q08999, Q64700
• Gene Symbols: RBL2
• Immunogen: Rb2 (p130) peptide corresponding to a region near the C-terminus of the human protein conjugated to KLH.
• Regulatory Status: RUO
• Gene ID (Entrez): 19651, 5934, 81758
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov