Invitrogen™ p130 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA126037

Catalog No. PIPA126037

Description

PA1-26037 detects Rb2 p130 from human, mouse, and rat samples.

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.

Specifications

• Antigen: p130
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RBL2
• Gene Alias: 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RB transcriptional corepressor like 2; Rb2; rb2 p130; Rbl2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related protein 2
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 19651, 5934, 81758
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% gelatin and 0.1% sodium azide
• Gene Accession No.: O55081, Q08999, Q64700
• Gene Symbols: RBL2
• Immunogen: Synthetic peptide corresponding to the C-terminal region of human Rb2 p130.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov