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MilliporeSigma™ p14ARF (p19ARF), Rabbit, Unlabeled, Polyclonal,

Catalog No. ABC1430MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ABC1430MI 100 μL Unconjugated
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Catalog No. ABC1430MI Supplier MilliporeSigma™ Supplier No. ABC1430
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Description

Rabbit Polyclonal Antibody

Platelet-Derived Growth Factor (PDGF) is the major serum mitogen for cells of mesenchymal origin in humans. The biologically active protein is a dimer composed of two related polypeptides designated A and B. The protein may exist as either a heterodimer AB or as a homodimer AA or BB. PDGF (BB) has been identified as the human homolog of the v-sis oncogene product and as such has been designated c-sis. The v-sis transforming domain is 89 amino acids in length and is identical in sequence to PDGF (BB). Binding of the PDGF molecule to its specific receptor occurs via interaction with a specific domain on the surface of the molecule known as the V4 surface domain. The PDGF protein has been implicated both directly as well as indirectly in several pathological states including neoplasia, arthritis, arteriosclerosis and bone marrow sclerosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p14ARF (p19ARF)
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene CDKN2A, CDKN2, MTS1
Gene Accession No. Q8N726
Host Species Rabbit
Immunogen KLH-conjugated linear peptide corresponding to human p14ARF (p19ARF)/smARF C-terminal end sequence.
Purification Method Affinity Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Apoptosis & Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_478102
Test Specificity This rabbit polyclonal antibody targets the C-terminal end sequence present in both ARF spliced isoforms, p14ARF (p19ARF) and smARF, reported by UniProt (Q8N726). This polyclonal antibody does not detect the INK4 spliced isoforms (UniProt P42771) also encoded by the CDKN2A gene.
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
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For Research Use Only. Not for use in diagnostic procedures.

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