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Invitrogen™ p27 Kip1 Monoclonal Antibody (3D8)
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Catalog No. PIMA515635
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100 μL
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Catalog No. Quantity
PIMA515635 100 μL
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Catalog No. PIMA515635 Supplier Invitrogen™ Supplier No. MA515635
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Description

Mouse Monoclonal Antibody

MA5-15635 targets CDKN1B in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15635 immunogen is purified recombinant fragment of human CDKN1B expressed in E. Coli. MA5-15635 detects CDKN1B which has a predicted molecular weight of approximately 22kDa.

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p27 Kip1
Applications ELISA, Western Blot
Classification Monoclonal
Clone 3D8
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene Cdkn1b
Gene Accession No. P46527
Gene Alias AA408329; AI843786; Cdki1b; CDKN1B; CDKN4; CDN1B; cyclin dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; cyclin-dependent kinase inhibitor p27/Kip1; KIP1; MEN1B; MEN4; p27; P27 CDKN1B; p27(KIP1); p27Kip1
Gene Symbols Cdkn1b
Host Species Mouse
Immunogen Purified recombinant fragment of human CDKN1B expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1027
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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