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p27 Kip1 Monoclonal Antibody (DCS-72.F6), Invitrogen™

Catalog No. PIAHZ0452
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100 μg
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PIAHZ0452 100 μg
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Catalog No. PIAHZ0452 Supplier Thermo Scientific Supplier No. AHZ0452

Description

Mouse Monoclonal Antibody

Suggested positive controls include HT29, MAD109, PC12 cells and brain tissue.

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p27 Kip1
Applications Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone DCS-72.F6
Concentration 0.2 mg/mL
Conjugate Unconjugated
Gene CDKN1B
Gene Accession No. Q6SLL5, P46527, P46414
Gene Alias CDKN1B, CDN1B, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, KIP1
Gene Symbols CDKN1B
Host Species Mouse
Immunogen Mouse recombit p27Kip1 protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1027, 12576, 403429, 83571
Target Species Canine, Human, Mouse, Rat
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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