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Invitrogen™ p27 Polyclonal Antibody
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Catalog No. PIPA528487
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100 μL
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PIPA528487 100 μL
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Catalog No. PIPA528487 Supplier Invitrogen™ Supplier No. PA528487
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431. Predicted reactivity: Mouse (98%), Rat (100%), Zebrafish (89%), Xenopus laevis (91%), Dog (99%), Pig (99%), Rabbit (99%), Chicken (96%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

p27, also known as p27Kip1, is a crucial cyclin-dependent kinase inhibitor (CKI) involved in the regulation of the cell cycle. The p27 protein is encoded by the CDKN1B gene located on chromosome 12 and plays a vital role in controlling cell proliferation by inhibiting cyclin-CDK complexes, particularly cyclin A-CDK2 and cyclin E-CDK2. By regulating these complexes, p27 induces cell cycle arrest at the G1 phase, preventing cells from prematurely entering the S phase. This function is critical for maintaining normal cellular processes and preventing uncontrolled cell division. p27 acts as a tumor suppressor, and its expression is tightly controlled by transcriptional and post-transcriptional mechanisms, including proteasome-mediated degradation. Reduced levels of p27 have been associated with numerous cancers, highlighting its role in tumorigenesis. The regulation of p27 involves signaling pathways such as the PI3K/AKT pathway, impacting its localization and stability in response to extracellular signals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p27
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene TMED7
Gene Accession No. Q9Y3B3
Gene Alias CGI-109; p24 family protein gamma-3; p24g3; p24gamma3; p27; TMED7; Transmembrane emp24 domain-containing protein 7; transmembrane emp24 protein transport domain containing 7; transmembrane p24 trafficking protein 7
Gene Symbols TMED7
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human TMED7. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51014
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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