Invitrogen™ P2X2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531318

Catalog No. PIPA531318

Description

Recommended positive controls: A549, HepG2, mouse brain. Predicted reactivity: Mouse (81%), Rat (80%), Bovine (86%), Guinea pig (83%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

P2rx2 are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. P2rx2 functions as a ligand-gated ion channel and binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for P2rx2. P2rx2 is involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, P2rx2 regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. P2rx2 also mediates synaptic transmission between neurons and from neurons to smooth muscle. Diseases associated with P2RX2 include Deafness, Autosomal Dominant 41 and Dfna41 Nonsyndromic Hearing Loss And Deafness.

Specifications

• Antigen: P2X2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: P2RX2
• Gene Alias: ATP receptor; DFNA41; MGC129601; P2RX2; P2X purinoceptor 2; P2X Receptor, subunit 2; P2X2; P2X2 purinoceptor; P2X2 receptor splice variant P2X2-1; P2X2 receptor splice variant P2X2-2; P2X2 receptor splice variant P2X2-3; P2X2a; Purinergic receptor; purinergic receptor P2X 2; purinergic receptor P2X, ligand gated ion channel, 2; purinergic receptor P2X, ligand-gated ion channel, 2; purinergic receptor P2X2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22953, 231602
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8K3P1, Q9UBL9
• Gene Symbols: P2RX2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 8 and 302 of Human P2X2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG