Invitrogen™ P2X6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587659

Catalog No. PIPA587659

Description

Immunogen sequence: WGLLDYKTEK WALLAKKGYQ ERDLEPQFSI ITKLKGVSVT QIKELGNRLW DVADFVKPPQ GENVFFLVTN FLVTPAQVQG RCPEHPSVPL ANCWVDEDCP EGEGGTHSHG VKTGQCVVFN GTHRTCEIWS WCPVESGVVP SRPLLAQAQN FTLFIKNTVT FSKFNFSKSN ALETWDPTYF KHCRYEPQFS PYCPVFRIGD LVAKAGGTFE DLALLGGSVG IRVHWDCDLD TGDSGCWPHY SFQLQEKSYN FRTATHWWEQ P; Positive Samples: Mouse pancreas; Cellular Location: Membrane, Multi-pass membrane protein.

P2rx6 encodes receptors that are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each P2rx6 receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. The protein encoded by the P2rx6 gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. The P2rx6 gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants of P2rx6.

Specifications

• Antigen: P2X6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: P2RX6
• Gene Alias: ATP receptor; P2RX6; P2RXL1; P2X purinoceptor 6; P2x6; P2X6 receptor; P2XM; Purinergic receptor; purinergic receptor P2X 6; purinergic receptor P2X, ligand gated ion channel, 6; purinergic receptor P2X, ligand-gated ion channel, 6; purinergic receptor P2X6; Purinergic receptor P2X-like 1; purinergic receptor P2X-like 1 orphan receptor; purinergic receptor P2X-like 1, orphan receptor; purinoceptor P2X6; purinoreceptor P2X6; Rnap2x6; skeletal muscle-expressed P2X
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18440
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.47 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O54803
• Gene Symbols: P2RX6
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human P2RX6 (NP_0011530261).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG