Invitrogen™ P2Y14 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596964

Catalog No. PIPA596964

Description

Immunogen sequence: ITKKIFKSHL KSSRNSTSVK KKSSRNIFSI VFVFFVCFVP YHIARIPYTK SQTEAHYSCQ SKEILRYMKE FTLLLSAANV CLDPIIYFFL CQPFREILCK KLHIPLKAQN DLDISRIKRG NTTLESTDTL; Positive Samples: Jurkat, U-937, SH-SY5Y, MCF7, Mouse spleen, Mouse lung, Mouse heart, Rat spleen, Rat lung; Cellular Location: Cell membrane, Multi-pass membrane protein.

GPR105 has been reported to be expressed in brain. ESTs have been isolated from kidney, placenta, uterus, and heart/melanocyte/uterus libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: P2Y14
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: P2RY14
• Gene Alias: A330108O13Rik; BPR105; G protein coupled receptor for UDP-glucose; G protein-coupled receptor 105; G protein-coupled receptor VTR 15-20; GPCR105; Gpr105; G-protein coupled receptor 105; KIAA0001; P2ry14; P2Y purinoceptor 14; P2Y(14) receptor; P2Y14; P2Y14 receptor; purinergic receptor P2Y, G-protein coupled, 14; purinergic receptor P2Y14; UDP-glucose receptor; VTR 15-20; VTR 15-20 receptor
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 140795, 171108, 9934
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.75 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O35881, Q15391, Q9ESG6
• Gene Symbols: P2RY14
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 209-338 of human P2RY14 (NP_0556943).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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