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P2Y14 Polyclonal Antibody, Invitrogen™

Catalog No. OPA115556
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25 μg
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Catalog No. Quantity
OPA115556 25 μg
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Catalog No. OPA115556 Supplier Thermo Scientific Supplier No. OPA115556

Description

Rabbit Polyclonal Antibody

By immunohistochemistry, OPA1-15556 detects GPR105 in formalin fixed, paraffin embedded human tissues.

GPR105 has been reported to be expressed in brain. ESTs have been isolated from kidney, placenta, uterus, and heart/melanocyte/uterus libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "e;turn-off"e; activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
TRUSTED_SUSTAINABILITY

Specifications

Antigen P2Y14
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene P2RY14
Gene Accession No. Q15391
Gene Alias A330108O13Rik; BPR105; G protein coupled receptor for UDP-glucose; G protein-coupled receptor 105; G protein-coupled receptor VTR 15-20; GPCR105; Gpr105; G-protein coupled receptor 105; KIAA0001; P2ry14; P2Y purinoceptor 14; P2Y(14) receptor; P2Y14; P2Y14 receptor; purinergic receptor P2Y, G-protein coupled, 14; purinergic receptor P2Y14; UDP-glucose receptor; VTR 15-20; VTR 15-20 receptor
Gene Symbols P2RY14
Host Species Rabbit
Immunogen Synthetic peptide, KLH conjugated, corresponding to to the 2nd extracellular domain of human G Protein-Coupled Receptor GPR105.
Purification Method Antigen affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9934
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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