Invitrogen™ p35 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578263

Catalog No. PIPA578263

Description

Positive Control: HeLa Predicted Reactivity: Mouse (100%), Rat (100%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Specifications

• Antigen: p35
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cdk5r1
• Gene Alias: 23 kDa subunit of tau-protein kinase II; cdk5 activator; CDK5 activator 1; CDK5P35; Cdk5r; Cdk5r1; cyclin dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 activator 1, p25; Cyclin-dependent kinase 5 activator 1, p35; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit (p35) 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); D11Bwg0379e; NCK5A; neuronal CDK5 activator; p23; p25; P25/P35; p35; p35nck5a; regulatory partner for CDK5 kinase; tau protein kinase II 23 kDa subunit; tau protein kinase II 23kDa subunit; TPKII regulatory subunit
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116671, 12569, 8851
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.97 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P61809, P61810, Q15078
• Gene Symbols: Cdk5r1
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Human p35. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG