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p35 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 183461AP

Catalog No. 50-173-2128


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Description

Description

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer ft.s disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer ft.s disease.
Specifications

Specifications

p35
0.22 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P61809, P61810, Q15078
CDK5 activator 1, CDK5P35, CDK5R, CDK5R1, NCK5A, p23, p25, p35, p35nck5a, TPKII regulatory subunit
Rabbit
IgG
150 μL
-20°C
Primary
116671, 12569, 8851
Immunoprecipitation, Western Blot
Unconjugated
CDK5R1
Liquid
CDK5R1
p35 Fusion Protein Ag13152
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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