Invitrogen™ p41-ARCb Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5143651

Catalog No. PIPA5143651

Description

The antibody detects a 41 kDa* protein corresponding to the molecular mass of Arpc1b on SDS-PAGE immunoblots of human A431 and Jurkat cells, rat A7r5 and PC12 cells, and mouse C2C12 cells.

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase.

Specifications

• Antigen: p41-ARCb
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARPC1B
• Gene Alias: 41kDa; AA408064; AA408534; AA571392; actin related protein 2/3 complex subunit 1B; actin related protein 2/3 complex subunit 1B, 41kDa; actin related protein 2/3 complex, subunit 1B; actin related protein 2/3 complex, subunit 1B, 41kDa; actin-related protein 2/3 complex subunit 1B; Actin-related protein complex 1b; AF007010; ARC41; Arp2/3 complex 41 kDa subunit; ARP2/3 protein complex subunit p41; Arpc1b; AW208418; L72; OTTHUMP00000206020; p40-ARC; p41-ARC; SOP2Hs
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10095, 11867, 54227
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
• Gene Accession No.: O15143, O88656, Q9WV32
• Gene Symbols: ARPC1B
• Immunogen: Arpc1b/p41-Arc synthetic peptide (coupled to KLH) corresponding to amino acid residues in the C-terminal region of human Arpc1b. This peptide sequence is highly conserved in rat, mouse, and chicken Arpc1b, and has some homology to the conserved region in isoform Arpc1a.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG