p53 Antibody (TRP/816), Alexa Fluor™ 405, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP259628AF405

Catalog No. NBP259628AI

Description

p53 Monoclonal specifically detects p53 in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockout Validated.

Specifications

• Antigen: p53
• Classification: Monoclonal
• Conjugate: Alexa Fluor 405
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: TP53
• Immunogen: Recombinant human full-length p53 protein (Uniprot: P04637)
• Quantity: 100 μL
• Research Discipline: Apoptosis, Cancer, Cell Cycle and Replication, Cellular Markers, Checkpoint signaling, Core ESC Like Genes, DNA Double Strand Break Repair, DNA Repair, HIF Target Genes, Hypoxia, Neuroscience, Neurotransmission, p53 Pathway, Phospho Specific, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors
• Gene ID (Entrez): 7157
• Target Species: Human
• Form: Purified

• Applications: Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoassay, Immunofluorescence
• Clone: TRP/816
• Dilution: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockout Validated
• Gene Alias: Antigen NY-CO-13, FLJ92943, LFS1TRP53, p53, p53 tumor suppressor, P53cellular tumor antigen p53, Phosphoprotein p53, transformation-related protein 53, tumor protein p53, Tumor suppressor p53
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
• Content And Storage: Store at 4C in the dark.
• Isotype: IgG2a κ

For Research Use Only (RUO)