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Invitrogen™ p53R2 Polyclonal Antibody
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Catalog No. PIPA519970
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100 μg
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Catalog No. Quantity
PIPA519970 100 μg
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Catalog No. PIPA519970 Supplier Invitrogen™ Supplier No. PA519970
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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~39kDa. A suggested positive control is A431 cell lysate. PA5-19970 can be used with blocking peptide PEP-0095.

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and -gamma-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p53R2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Rrm2b
Gene Accession No. Q6PEE3, Q7LG56
Gene Alias MTDPS8A; MTDPS8B; p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2 short form beta; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; Ribonucleoside-diphosphate reductase subunit M2 B; ribonucleotide reductase M2 B (TP53 inducible); ribonucleotide reductase regulatory TP53 inducible subunit M2B; RRM2B; TP53-inducible ribonucleotide reductase M2 B
Gene Symbols Rrm2b
Host Species Rabbit
Immunogen A synthetic peptide corresponding to amino acids 16 of human p53R2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 299976, 382985, 50484
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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