p65/RELA Mouse anti-Human, Rat, Clone: 1B12D11, Proteintech

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-6956	Proteintech Group Inc 665351IG150UL	150 μL

Description

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: p65/RELA
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: NFKB3, p65, RELA, Transcription factor p65
• Gene Symbols: Rela
• Isotype: IgG1
• Purification Method: Protein G
• Product Type: Antibody

• Clone: 1B12D11
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human, Rat
• Gene Accession No.: Q04206
• Gene ID (Entrez): 309165, 5970
• Immunogen: p65; RELA Fusion Protein Ag1199
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: RELA