p65/RELA Rabbit anti-Human, Mouse, Porcine, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-6560	150 μL

Catalog No. 50-172-6560 Supplier Proteintech Group Inc Supplier No. 107451AP150UL

Description

Rabbit Polyclonal Antibody

This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human RELA.

The transcription factor NFkB is widely recognized as a critical mediator of immune and inflammatory responses. In most cell types, NFkB is found in the cytoplasm where it is associated with an inhibitory protein known as IkB. An impressive variety of stimuli (tumor necrosis factor, interleukin 1, T-cell activation signals, bacterial endotoxins, viral transforming proteins, certain growth factors and reactive oxygen intermediates) lead to the rapid nuclear assumulation of NFkB by the induced phosphorylation and subsquent degradation of IkB. In the nucleus, NFkB regulates genes encoding cytokines, cytokine receptors, cell adhesion molecules, proteins involved in coagulation and genes involved in cell growth control. Additionally, NFkB is thought to be an important transcriptional regulator for HIV. Growing evidence indicates that the dysregulation of NFkB may be key to a number of diseases including arthritis and other inflammatory diseases, Alzheimer′s disease, atherosclerosis, and cancer.

Specifications

• Antigen: p65/RELA
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
• Classification: Polyclonal
• Concentration: 0.52 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: RELA
• Gene Accession No.: Q04206, Q04207
• Gene Alias: NFKB 3, NFKB p65, NFKB3, p65, RELA, Transcription factor p65
• Gene Symbols: RELA
• Host Species: Rabbit
• Immunogen: p65; RELA Fusion Protein Ag1199
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100135665, 19697, 309165, 5970
• Target Species: Human, Mouse, Pig, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG