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  5. Tocris Bioscience™ PA 8

Tocris Bioscience™ PA 8
GREENER_CHOICE

Catalog No. 665750
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

PAC1 receptor antagonist

PA 8 is a PAC1 receptor antagonist. Inhibits PACAP-induced CREB phosphorylation in PAC1, but not VPAC1 or VPAC2, expressing cells. Also inhibits PACAP-induced increases in cAMP levels in vitro (IC50 = 2 nM) and PACAP-induced aversive responses and mechanical allodynia following intrathecal injection in vivo.

Specifications

Chemical Name or Material 2-Amino-5,8-dihydro-5-[3-methoxy-4-(2-propen-1-yloxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione
CAS 878437-15-1
Quantity 50 mg
Molecular Formula C17H18N4O4
Formula Weight 342.35
Purity 98%
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