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PA1 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501572306
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50-157-2306 10 μL
50-157-2305 100 μL
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Catalog No. 50-157-2306 Supplier Bethyl Laboratories, Inc Supplier No. IHC00560T
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Horse, Orangutan, Monkey, Gorilla, Chimpanzee, Little brown bat, hirteen-lined ground squirrel an

Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators, but they have recently been determined to co-regulate transcription initiated by other transcription factors. GAS is a recently identified glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1, the other two members of the SRC family. GAS can also interact with the alpha subunit of the estrogen receptor (ERalpha), but not other receptors such as the retinoic acid receptor a, suggesting the interaction between GAS and ERalpha is relatively specific. Depletion of GAS by RNA interference in MCF7 cells led to a decrease in the mRNA and protein levels of ER target genes such as pS2, c-Myc and cyclin D1, indicating the role of GAS in the regulation of ER target genes. GAS has also been found to associate with an SET1-like methyltransferase complex specific for H3K4 methylation, suggesting that GAS has multiple roles in transcriptional regulation.

Specifications

Antigen PA1
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene PAGR1
Gene Accession No. Q9BTK6
Gene Alias GAS, PA1; PAXIP1-associated protein 1; PTIP-associated 1 protein; PTIP-associated protein 1; glutamate-rich coactivator interacting with SRC1/NCOA1
Gene Symbols PAGR1
Host Species Rabbit
Immunogen Between 204 and 254
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79447
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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