Invitrogen™ PAAF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA559008

Catalog No. PIPA559008

Description

Immunogen sequence: GNIYQLDVRS PRAPVQVIHR SGAPVLSLLS VRDGFIASQG DGSCFIVQQD LDYVTELTGA DCDPVYKVAT WEKQIYTCCR DGLVRRYQLS DL Highest antigen sequence identity to the following orthologs: Mouse - 20%, Rat - 22%.

PAAF1 inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency.

Specifications

• Antigen: PAAF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PAAF1
• Gene Alias: PAAF; PAAF1; proteasomal ATPase associated factor 1; proteasomal ATPase-associated factor 1; Protein G-16; Rpn14; WD repeat domain 71; WD repeat-containing protein 71; WDR71
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80227
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BRP4
• Gene Symbols: PAAF1
• Immunogen: Recombinant protein corresponding to Human PAAF1. Recombinant protein control fragment (Product #RP-97489).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov