PABP4 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-157-2308	Bethyl Laboratories, Inc IHC00561T	10 μL
50-157-2307	Bethyl Laboratories, Inc IHC00561	100 μL

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Dog, Horse, Guinea pig_10141, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpan

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PABP4
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: APP-1, APP1, PABP4, iPABP, PABP-4, activated-platelet protein 1, inducible poly(A)-binding protein, poly(A)-binding protein 4, polyadenylate-binding protein 4
• Immunogen: Between 525 and 575
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: PABPC4

• Applications: Immunohistochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q13310
• Gene ID (Entrez): 230721, 8761
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody