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PABP4 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Catalog No. 501560467
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50-156-0467 100 μL
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Catalog No. 50-156-0467 Supplier Bethyl Laboratories, Inc Supplier No. A301466A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

Antigen PABP4
Applications Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/ml
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene PABPC4
Gene Accession No. Q13310
Gene Alias APP-1, APP1, PABP4, iPABP, PABP-4, activated-platelet protein 1, inducible poly(A)-binding protein, poly(A)-binding protein 4, polyadenylate-binding protein 4
Gene Symbols PABPC4
Host Species Rabbit
Immunogen Between 525 and 575
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 230721, 8761
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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