Invitrogen™ PABPC4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555575

Catalog No. PIPA555575

Description

Immunogen sequence: RPQGFQGMPS AIRQSGPRPT LRHLAPTGSE CPDRLAMDFG GAGAAQQGLT DSCQSGGVPT AVQNLAPRAA VAAAAP Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 95%.

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PABPC4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PABPC4
• Gene Alias: Activated-platelet protein 1; APP1; APP-1; Inducible poly(A)-binding protein; iPABP; PABP4; PABP-4; PABPC4; poly(A) binding protein cytoplasmic 4; poly(A) binding protein, cytoplasmic 4; poly(A) binding protein, cytoplasmic 4 (inducible form); poly(A)-binding protein 4; polyadenylate-binding protein 4
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8761
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.8 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q13310
• Gene Symbols: PABPC4
• Immunogen: Recombinant protein corresponding to Human PABPC4. Recombinant protein control fragment (Product #RP-94047).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov