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Invitrogen™ PABPC4 Polyclonal Antibody
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Catalog No. PIPA576190
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100 μL
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Catalog No. Quantity
PIPA576190 100 μL
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Catalog No. PIPA576190 Supplier Invitrogen™ Supplier No. PA576190
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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PABPC4
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene PABPC4
Gene Accession No. Q13310
Gene Alias Activated-platelet protein 1; APP1; APP-1; Inducible poly(A)-binding protein; iPABP; PABP4; PABP-4; PABPC4; poly(A) binding protein cytoplasmic 4; poly(A) binding protein, cytoplasmic 4; poly(A) binding protein, cytoplasmic 4 (inducible form); poly(A)-binding protein 4; polyadenylate-binding protein 4
Gene Symbols PABPC4
Host Species Rabbit
Immunogen Synthetic peptide of human PABPC4.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 230721, 298510, 8761
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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