PABPN1 Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-156-5373	20 μL

Catalog No. 50-156-5373 Supplier Bethyl Laboratories, Inc Supplier No. A303524AT

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails on the 3′ ends of eukaryotic genes and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5′ end of the coding region of this gene leads to autosomal domit oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed.

Specifications

• Antigen: PABPN1
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: PABPN1
• Gene Accession No.: Q86U42
• Gene Alias: OPMD, PAB2, PABII, PABP-2, PABP2, poly(A) binding protein 2, poly(A) binding protein II, polyadenylate-binding protein 2
• Gene Symbols: PABPN1
• Host Species: Rabbit
• Immunogen: Between 100 and 150
• Purification Method: Antigen affinity chromatography
• Quantity: 20 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8106
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG