PACRGRabbit anti-Chicken, Human, Mouse, Polyclonal, Rockland™

Catalog No.	Quantity
50-199-1766	100 μg

Catalog No. 50-199-1766 Supplier Rockland Immunochemicals Supplier No. 600401474

Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against human PACRG protein. A BLAST analysis was used to suggest reactivity with this protein from human, mouse and chicken based on 100% homology for the immunogen sequence. Cross reactivity with PACRG protein from zebrafish and rat may occur as this sequence only varies by one amino acid residue (94% homology). Expect reactivity with both splice variants of this protein. Cross reactivity with PACRG homologues from other sources has not been determined.

PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death.

Specifications

• Antigen: PACRG
• Applications: ELISA, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1.6 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene: PACRG
• Gene Accession No.: Q96M98, Q9DAK2
• Gene Alias: 1700008H23Rik; BOS_10014; FLJ32724; GLUP; HAK005771; Hypertension-related protein 1-like protein; LOC100342049; Molecular chaperone/chaperonin-binding protein; PACRG; PARK2 coregulated; PARK2 co-regulated; PARK2 coregulated gene protein; PARK2CRG; parkin coregulated; Parkin coregulated gene protein; parkin co-regulated gene protein; Parkin coregulated gene protein homolog; RGD1561027; RP3-495O10.2; zgc:101786
• Gene Symbols: PACRG
• Host Species: Rabbit
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 135138, 421576, 69310
• Target Species: Chicken, Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid