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Invitrogen™ PACS1 Polyclonal Antibody
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Catalog No. PIPA558589
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100 μL
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PIPA558589 100 μL
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Catalog No. PIPA558589 Supplier Invitrogen™ Supplier No. PA558589
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DTTSPMELAA LEKIKSTWIK NQDDSLTETD TLEITDQDMF GDASTSLVVP EKVKTPMKSS KTDLQGSASP SKVEGVHTPR QKRSTPLKER QLSKPLSE Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.

PACS-1 (CRA_a) is a 963 amino acid rich regulatory protein involved in protein trafficking and belongs to the PACS family. A coat protein involved in controlling the correct subcellular localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs, PACS-1 is also known to be involved in HIV-1 Nef-mediated removal of MHC-I from the cell surface to the TGN, thus enabling HIV-1 to escape immune surveillance. PACS-1 also controls the endosome to Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin coated membrane pits. Usually seen in golgi apparatus, trans-Golgi network and localized in the paranuclear region, it is ubiquitously expressed in most of the tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PACS1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PACS1
Gene Accession No. Q6VY07
Gene Alias AI325977; cytosolic sorting protein PACS-1; KIAA1175; LOW QUALITY PROTEIN: phosphofurin acidic cluster sorting protein 1; phosphofurin acidic cluster sorting protein 1; MRD17; PACS1; PACS-1; Phosphofurin acidic cluster sorting protein 1
Gene Symbols PACS1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PACS1. Recombinant protein control fragment (Product #RP-97484).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55690
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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