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Invitrogen™ PACS1 Polyclonal Antibody
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Catalog No. PIPA523291
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100 μg
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PIPA523291 100 μg
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Catalog No. PIPA523291 Supplier Invitrogen™ Supplier No. PA523291
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Description

Rabbit Polyclonal Antibody

Immunogen sequence homology: Opossum/Canine (89%).

PACS-1 (CRA_a) is a 963 amino acid rich regulatory protein involved in protein trafficking and belongs to the PACS family. A coat protein involved in controlling the correct subcellular localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs, PACS-1 is also known to be involved in HIV-1 Nef-mediated removal of MHC-I from the cell surface to the TGN, thus enabling HIV-1 to escape immune surveillance. PACS-1 also controls the endosome to Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin coated membrane pits. Usually seen in golgi apparatus, trans-Golgi network and localized in the paranuclear region, it is ubiquitously expressed in most of the tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PACS1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene PACS1
Gene Accession No. Q6VY07, Q8K212
Gene Alias AI325977; cytosolic sorting protein PACS-1; KIAA1175; LOW QUALITY PROTEIN: phosphofurin acidic cluster sorting protein 1; phosphofurin acidic cluster sorting protein 1; MRD17; PACS1; PACS-1; Phosphofurin acidic cluster sorting protein 1
Gene Symbols PACS1
Host Species Rabbit
Immunogen A portion of amino acids 300-350 of human PACS-1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100052235, 107975, 483716, 514313, 55690
Target Species Human, Mouse, Canine, Monkey, Bovine, Horse, Marsupial
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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