Invitrogen™ PACS2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100167

Catalog No. PIPA5100167

Description

Antibody detects endogenous levels of total PACS2.

PACS2 is the multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, PACS2 translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death.PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Specifications

• Antigen: PACS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PACS2
• Gene Alias: 6720425G15Rik; AW208651; AW489976; E230011J22; FLJ25488; Kiaa0602; mKIAA0602; Pacs1l; PACS1-like protein; Pacs2; PACS-2; Phosphofurin acidic cluster sorting protein 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 217893, 23241, 691631
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q3V3Q7, Q86VP3
• Gene Symbols: PACS2
• Immunogen: A synthesized peptide derived from human PACS2(Accession Q86VP3), corresponding to amino acid residues S707-P757.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov