Invitrogen™ PACSIN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590737

Catalog No. PIPA590737

Description

Immunogen sequence: KRLVFLKEVL LDIKRHLNLA ENSSYIHVYR ELEQAIRGAD AQEDLRWFRS TSGPGMPMNW PQFEEWNPDL PHTTTKKEKQ PKKAEGVALT NATGAVESTS QAGDRGSVSS YDRGQPYATE WSDDESGNPF GGSETNGGAN PFEDDSKGVR V; Positive Samples: U-251MG; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle membrane, Membrane, Peripheral membrane protein, cytosol, ruffle membrane, synapse, synaptosome.

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Specifications

• Antigen: PACSIN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pacsin1
• Gene Alias: A830061D09Rik; Dynamin PRD-interacting protein; dynamin proline-rich domain-interacting protein; H74; KIAA1379; mKIAA1379; Pacsin; Pacsin1; protein kinase C and casein kinase substrate in neurons 1; protein kinase C and casein kinase substrate in neurons protein 1; SdpI; synaptic, dynamin-associated protein I; syndapin; syndapin 1; syndapin I; syndapin-1; Syndapin-I
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29993
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.08 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9BY11
• Gene Symbols: Pacsin1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 240-390 of human PACSIN1 (NP_0658551).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov