Invitrogen™ PADI4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110070

Catalog No. PIPA5110070

Description

Immunogen sequence: VFRVAPWIMT PNTQPPQEVY ACSIFENEDF LKSVTTLAMK AKCKLTICPE EENMDDQWMQ DEMEIGYIQA PHKTLPVVFD SPRNRGLKEF PIKRVMGPDF GYVTRGPQTG GISGLDSFGN LEVSPPVTVR GKEYPLGRIL FGDSCYPSND SRQMHQALQD FLSAQQVQAP VKLYSDWLSV GHVDEFLSFV PAPDRKGFRL LLASPRSCYK LFQEQQNEGH GEALLFEGIK KKKQQKIKNI LSNKTLREHN SFVERCIDWN RELLKRELGL AESDIIDIPQ LFKLKEFSKA EAFFPNMVNM LVLGKHLGIP KPFGPVINGR CCLEEKVCSL LEPLGLQCTF INDFFTYHIR HGEVHCGTNV RRKPFSFKWW NMVP.

Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.

Specifications

• Antigen: PADI4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Padi4
• Gene Alias: HL-60 PAD; PAD; PAD type IV; PAD4; Padi4; PADI5; PADI-H protein; PAD-R4; Pdi4; PDI5; peptidyl arginine deiminase 4; peptidyl arginine deiminase, type 4; peptidyl arginine deiminase, type IV; peptidyl arginine deiminase, type V; peptidylarginine deiminase IV; Peptidylarginine deiminase type alpha; protein-arginine deiminase type IV; Protein-arginine deiminase type-4
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18602, 23569, 29512
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.08 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: O88807, Q9UM07, Q9Z183
• Gene Symbols: Padi4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 290-663 of human PADI4 (NP_0365192).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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