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Invitrogen™ PAG1 Polyclonal Antibody
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Catalog No. PIPA581959
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100 μL
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PIPA581959 100 μL
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Catalog No. PIPA581959 Supplier Invitrogen™ Supplier No. PA581959
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PVPVKLLDEN ENLQEKEGGE AEESATDTTS ETNKRFSSLS YKSREEDPTL TEEEISAMYS SVNKPGQLVN KSGQSLTVPE STYTSIQGDP QRSPSSCNDL YATVKDFEKT PNSTLPPAG Highest antigen sequence indentity to the following orthologs: Rat - 63%, Mouse - 73%.

PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PAG1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PAG1
Gene Accession No. Q9NWQ8
Gene Alias CBP; Csk binding protein; csk-binding protein; F730007C19Rik; Pag; PAG 1; Pag1; PAG1B; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; phosphoprotein membrane anchor with glycosphingolipid microdomains 1; phosphoprotein transmembrane adaptor 1; phosphoprotein-associated with GEMs; pregnancy-associated glycoprotein 1; Pregnancy-specific protein B; PSP-B; similar to pregnancy-associated glycoprotein 1; transmembrane adapter protein PAG; transmembrane adaptor protein PAG; transmembrane phosphoprotein Cbp
Gene Symbols PAG1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PAG1. Recombinant protein control fragment (Product #RP-102112).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55824
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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