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Invitrogen™ PAG1 Polyclonal Antibody
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Catalog No. PIPA5115714
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Quantity:
100 μL
Catalog No. Quantity
PIPA5115714 100 μL
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Catalog No. PIPA5115714

Supplier: Invitrogen™ PA5115714

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PAG.

PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PAG1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene PAG1
Gene Accession No. Q3U1F9, Q9JM80, Q9NWQ8
Gene Alias CBP; Csk binding protein; csk-binding protein; F730007C19Rik; Pag; PAG 1; Pag1; PAG1B; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; phosphoprotein membrane anchor with glycosphingolipid microdomains 1; phosphoprotein transmembrane adaptor 1; phosphoprotein-associated with GEMs; pregnancy-associated glycoprotein 1; Pregnancy-specific protein B; PSP-B; similar to pregnancy-associated glycoprotein 1; transmembrane adapter protein PAG; transmembrane adaptor protein PAG; transmembrane phosphoprotein Cbp
Gene Symbols PAG1
Host Species Rabbit
Immunogen A synthesized peptide derived from human PAG1(Accession Q9NWQ8), corresponding to amino acid residues V108-G158.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55824, 64019, 94212
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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