Invitrogen™ PAG1 Recombinant Rabbit Monoclonal Antibody (0K5F4)

Catalog No.	Quantity
PIMA537900	100 μL

Catalog No. PIMA537900 Supplier Invitrogen™ Supplier No. MA537900

Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: Raji, SH-SY5Y, Mouse brain, Mouse spleen, Rat lung, Rat brain, Rat spleen Immunogen sequence: SLTVPESTYT SIQGDPQRSP SSCNDLYATV KDFEKTPNST LPPAGRPSEE PEPDYEAIQT LNREEEKATL GTNGHHGLVP KENDYESISD LQQGRDITRL.

PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.

Specifications

• Antigen: PAG1
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 0K5F4
• Concentration: 1.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: PAG1
• Gene Accession No.: Q3U1F9, Q9JM80, Q9NWQ8
• Gene Alias: CBP; Csk binding protein; csk-binding protein; F730007C19Rik; Pag; PAG 1; Pag1; PAG1B; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; phosphoprotein membrane anchor with glycosphingolipid microdomains 1; phosphoprotein transmembrane adaptor 1; phosphoprotein-associated with GEMs; pregnancy-associated glycoprotein 1; Pregnancy-specific protein B; PSP-B; similar to pregnancy-associated glycoprotein 1; transmembrane adapter protein PAG; transmembrane adaptor protein PAG; transmembrane phosphoprotein Cbp
• Gene Symbols: PAG1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 333-432 of human PAG1 (Q9NWQ8).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55824, 64019, 94212
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG