Invitrogen™ PAGR1 Polyclonal Antibody

Catalog No.	Quantity
PIPA559574	100 μL

Catalog No. PIPA559574 Supplier Invitrogen™ Supplier No. PA559574

Description

Rabbit Polyclonal Antibody

Immunogen sequence: PAEEDSEDWC VPCSDEEVEL PADGQPWMPP PSEIQRLYEL LAAHGTLELQ AEILPRRPPT PEAQSEEERS DEEPEA Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 91%.

Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators, but they have recently been determined to co-regulate transcription initiated by other transcription factors. GAS is a recently identified glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1, the other two members of the SRC family. GAS can also interact with the alpha subunit of the estrogen receptor (ERalpha), but not other receptors such as the retinoic acid receptor a, suggesting the interaction between GAS and ERalpha is relatively specific. Depletion of GAS by RNA interference in MCF7 cells led to a decrease in the mRNA and protein levels of ER target genes such as pS2, c-Myc and cyclin D1, indicating the role of GAS in the regulation of ER target genes. GAS has also been found to associate with an SET1-like methyltransferase complex specific for H3K4 methylation, suggesting that GAS has multiple roles in transcriptional regulation.

Specifications

• Antigen: PAGR1
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: PAGR1
• Gene Accession No.: Q9BTK6
• Gene Alias: 2900092E17Rik; C16orf53; C77040; GAS; glutamate-rich coactivator associated with SRC1; glutamate-rich coactivator interacting with SRC1; glutamate-rich coactivator interacting with SRC1/NCOA1; PA1; Pagr; PAGR1; Pagr1a; PAXIP1 associated glutamate rich protein 1; PAXIP1 associated glutamate rich protein 1A; PAXIP1 associated glutamate-rich protein 1; PAXIP1-associated glutamate-rich protein 1; PAXIP1-associated glutamate-rich protein 1A; PAXIP1-associated protein 1; PTIP-associated 1; PTIP-associated 1 protein; PTIP-associated protein 1
• Gene Symbols: PAGR1
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human PAGR1. Recombinant protein control fragment (Product #RP-98796).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 79447
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG