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Invitrogen™ PAK4 Monoclonal Antibody (OTI1C7)
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Catalog No. PIMA526859
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100 μL
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PIMA526859 100 μL
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Catalog No. PIMA526859 Supplier Invitrogen™ Supplier No. MA526859
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Description

Mouse Monoclonal Antibody

PAK4 Monoclonal Antibody for IHC (P), Western Blot

PAK4 is a serine/ threonine p21 activating kinase implicated in the reorganization of actin cytoskeleton and in the formation of filopodia. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. The second group includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PAK4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1C7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Pak4
Gene Accession No. O96013
Gene Alias 5730488L07Rik; AW555722; hypothetical protein LOC431769; im:5916170; Kiaa1142; mKIAA1142; p21 (CDKN1A)-activated kinase 4; p21 (RAC1) activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; Pak4; PAK-4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; serine/threonine-protein kinase PAK 4; wu:fd12b01; zgc:92014
Gene Symbols Pak4
Host Species Mouse
Immunogen Human recombinant protein fragment corresponding to amino acids 1-308 of PAK4 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10298, 292756
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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