PALB2 Mouse anti-Human, Clone: OTI1E7, liquid, TrueMAB™

Catalog No.	Quantity
50-168-1152	100 μL

Catalog No. 50-168-1152 Supplier OriGene Supplier No. TA806541

Description

Mouse Monoclonal Antibody

The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.

Specifications

• Antigen: PALB2
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI1E7
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: PALB2
• Gene Accession No.: Q86YC2
• Gene Alias: FANCN, PNCA3
• Gene Symbols: PALB2
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-287 of human PALB2 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 79728
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1