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Invitrogen™ PALB2 Polyclonal Antibody
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Catalog No. PA548258
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400 μL
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PA548258 400 μL
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Catalog No. PA548258 Supplier Invitrogen™ Supplier No. PA548258
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Description

Rabbit Polyclonal Antibody

PALB2 Polyclonal Antibody for Flow, ICC/IF, Western Blot

The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PALB2
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene Palb2
Gene Accession No. Q86YC2
Gene Alias BC066140; FANCN; FLJ21816; PALB2; Partner and localizer of BRCA2; PNCA3; RGD1304759
Gene Symbols Palb2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 546-574 amino acids from the Central region of human PALB2.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79728
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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