Invitrogen™ Pan-cadherin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 717100

Catalog No. 71-710-0

Description

This peptide antibody is broadly cross-reactive with all members of the cadherin family of proteins including N-cadherin, E-cadherin, P-cadherin, and R-cadherin. The antibody also displays broad species cross-reactivity including human, bovine, mouse, rat, chicken, amphibian, as well as other species. Rabbit anti-pan-Cadherin is useful as both a ubiquitous cadherin probe as well as a marker for adherens junctions. 71-7100 was used successfully in the immunofluorescence analysis of pan cadherin in MDCK cells.

Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Specifications

• Antigen: Pan-cadherin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDH1
• Gene Alias: 2600010P09Rik; 4930525N21Rik; AA960649; AF020312; AI385538; AI851787; Arc-1; ATP-dependent helicase CHD1; ATP-dependent helicase CHD3; AW120700; AW555109; B-cadherin; CAD4; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1 S homeolog; cadherin 1, type 1, E-cadherin (epithelial); cadherin 15, M-cadherin (myotubule); cadherin 2; cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3; cadherin 3, P-cadherin (placental); cadherin 3, type 1, P-cadherin (placental); cadherin 4; cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; Cadherin-1; Cadherin-2; cadherin-3; Cadherin-4; cadherin-E; Cadherin-N; Cadp; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; cdh1; cdh1.S; Cdh2; Cdh3; Cdh4; Cdh4l; CDHE; CDHN; Cdhp; CDw325; CDw325 antigen; cell-CAM 120/80; CHD1; CHD-1; CHD3; CHD-3; Chd7; chromodomain helicase DNA binding protein 1; chromodomain helicase DNA binding protein 3; chromodomain-helicase-DNA-binding protein 1; Chromodomain-helicase-DNA-binding protein 3; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; HJMD; hZFH; K-CAM; LCAM; L-CAM; Liver cell adhesion molecule; liver cell adhesion protein; liver cell adhesion protein precursor; LOC108702627; Maternally-expressed neural cadherin; Mi-2 alpha; mi-2 autoantigen 240 kDa protein; Mi-2a; Mi2-ALPHA; Ncad; N-cadherin; N-cadherin 1; Neural cadherin; neural calcium-dependent cell adhesion molecule; Neural-cadherin; Pan Cadherin; PCAD; P-cadherin; P-cadherin (AA 232-723); Placental cadherin; Placental-cadherin; Prp7; Prp9-1; RCAD; R-CAD; R-Cadh; R-cadherin; retina cadherin; retinal cadherin; RPE-specific cadherin; Um; Unknown (protein for IMAGE:8237502); unnamed protein product; UVO; Uvomorulin; XELAEV_18024918mg; XELAEV_18046239mg; XmN-cadherin; xTCAD-1; ZFH; zinc finger helicase; zinc-finger helicase (Snf2-like)
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1000, 1001, 1002, 100337618, 100685099, 108702627, 114588, 116777, 12550, 12558, 12560, 12561, 414745, 414845, 415860, 419222, 442858, 480169, 611010, 83501, 83502, 999
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: F1PAA9, P08641, P09803, P10287, P10288, P12830, P15116, P19022, P22223, P24503, P30944, P39038, P55283, P79883, Q63149, Q9R0T4, Q9Z1Y3
• Gene Symbols: CDH1, cdh1.S, CDH2, CDH3, CDH4, LOC108702627
• Immunogen: Synthetic peptide derived from the carboxy-terminus of the chicken N-cadherin protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Monkey, Chicken, Frog
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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