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MilliporeSigma™ Pan DIDO, Rabbit, Unlabeled, Polyclonal,

Catalog No. ABN1367MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ABN1367MI 100 μg Unconjugated
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Catalog No. ABN1367MI Supplier MilliporeSigma™ Supplier No. ABN1367
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Description

Rabbit Polyclonal Antibody

Death-inducer obliterator 1 (UniProt Q9BTC0; also known as DATF-1, Death-associated transcription factor 1, DIO-1, hDido1) is encoded by the DIDO1 (also known as C20orf158, DATF1, KIAA0333) gene (Gene ID 11083) in human. The DIDO1 gene encodes four alternatively spliced variants (DIDO1/isoform 2, DIDO2/isoform 1, DIDO3/isoform 4, isoform a/isoform 3) implicated to be involved in apoptosis and development. The longest and most widely expressed DIDO3 is assigned as the canonical isoform. DIDO3 is a nuclear protein that forms part of the spindle assembly checkpoint (SAC) and is necessary for correct chromosome segregation in somatic and germ cells. Dido3-knockout compromises differentiation of murine embryonic stem cells (mESCs) in vitro and of epiblast cells in vivo, resulting in early embryonic death at around day 8.5 of gestation. On the other hand, exogenous expression of Dido1 isoform in mESCs is reported to inhibit LIF withdrawal-induced differentiation, while Dido1 knockdown facilitate mESCs differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Pan DIDO
Applications Western Blot
Classification Polyclonal
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene DIDO1, C20orf158, DATF1, KIAA0333
Gene Accession No. Q9BTC0
Host Species Rabbit
Immunogen KLH-conjugated linear peptide corresponding an N-terminal sequence of human DIDO1.
Purification Method Affinity Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_071388
Test Specificity This polyclonal antibody detects an N-terminal epitope present in all four spliced isoforms of human DIDO1 reported by UniProt (Q9BTC0).
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
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For Research Use Only. Not for use in diagnostic procedures.

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