Invitrogen™ Pan Ras Recombinant Rabbit Monoclonal Antibody (JF10-11)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA532561

Catalog No. PIMA532561

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Specifications

• Antigen: Pan Ras
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P01111, P01112, P01116, P08556, P08644, P20171, P32883, P79737, Q04970, Q61411
• Gene Symbols: HRAS, hrasa, KRAS, Nras
• Immunogen: Synthetic peptide within Human Ras aa 21-64.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Zebrafish
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry, Western Blot
• Clone: JF10-11
• Conjugate: Unconjugated
• Gene: Nras
• Gene Alias: AI929937; ALPS4; AV095280; C-BAS/HAS; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; CFC2; c-Ha-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; C-HA-RAS1; c-has/bas p21 protein; C-H-RAS; c-Ki-ras; c-Kirsten-ras protein; c-Kirsten-ras proto-oncogene; c-K-ras; c-K-ras2 protein; CMNS; c-rasHa; c-ras-Ki-2 activated oncogene; CTLO; etID18709.8; fa04e08; fc14b12; fc23g10; fj89d12; fj99a10; GTP- and GDP-binding peptide B; GTPase HRas; GTPase HRas, N-terminally processed; GTPase Hras1; GTPase KRas; GTPase KRas, N-terminally processed; GTPase NRas; HAMSV; Ha-ras; Ha-Ras1 proto-oncoprotein; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; Harvey rat sarcoma virus oncogene; Harvey rat sarcoma virus oncogene 1; Harvey-ras; hras; H-ras; H-ras 1 protein; HRas proto-oncogene, GTPase; HRas proto-oncogene, GTPase a; HRAS1; H-Ras-1; Hras-1; hrasa; H-RASIDX; hypothetical protein LOC445289; hypothetical protein LOC550286; K RAS; Ki-ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral oncogene; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); Kras; K-ras; K-Ras 2; K-ras p21 protein; KRAS proto-oncogene, GTPase; KRAS1; KRAS2; Kras-2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; NCMS; Neuroblastoma RAS; neuroblastoma ras oncogene; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; NRAS; N-ras; N-ras oncogene p21; N-ras protein part 4; NRAS proto-oncogene, GTPase; NRAS1; NS; NS3; NS6; oncogene KRAS2; p19 H-RasIDX protein; p21; p21 N-ras oncogene; p21 protein; p21B; p21ras; PR310 c-K-ras oncogene; RALD; ras; Ras family small GTP binding protein H-Ras; RASH1; RASK; RASK2; ras-like protein; RASN; sb:eu826; transformation gene: oncogene HAMSV; transforming protein N-Ras; Transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ha-ras Harvey rat sarcoma viral oncogene homolog a; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; v-ras neuroblastoma RAS viral oncogene homolog; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12; wu:fj99a10; xRAS1; xRAS2; zgc:100761; zgc:110250; zgc:85725; zras-b1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 15461, 16653, 18176, 24525, 24605, 293621, 30380, 3265, 3845, 445289, 4893, 550286
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid