Invitrogen™ Pan SHANK Monoclonal Antibody (N23b/49), APC

Catalog No.	Quantity
PIMA545438	100 μg

Catalog No. PIMA545438

Supplier: Invitrogen™ MA545438

Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45438 was sufficient for detection of Shank1-4 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 160kDa. Recognizes Shank1, 2 and 3.

Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina. Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease.

Specifications

• Antigen: Pan SHANK
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry, Microarray
• Classification: Monoclonal
• Clone: N23b/49
• Concentration: 1 mg/mL
• Conjugate: APC
• Formulation: 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
• Gene: SHANK2
• Gene Accession No.: D3YZU1, Q4ACU6, Q80Z38, Q9BYB0, Q9JLU4, Q9QX74, Q9UPX8, Q9WV48, Q9Y566
• Gene Alias: AI841104; AUTS17; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CORTBP1; CTTNBP1; DEL22q13.3; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; KIAA1022; Kiaa1650; mKIAA1022; proline rich synapse associated protein 1; proline rich synapse associated protein 2; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; Proline-rich synapse-associated protein 2; ProSAP1; Prosap2; PSAP2; SAPAP-interacting protein synamon; SCZD15; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains 3; SH3 and multiple ankyrin repeat domains protein 1; SH3 and multiple ankyrin repeat domains protein 2; SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-3; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-2; SH3/ankyrin domain gene 1; SH3/ankyrin domain gene 2; SH3/ankyrin domain gene 3; SHANK; shank postsynaptic density protein; Shank postsynaptic density protein 3a; SHANK1; Shank1a; Shank2; Shank3; shank3 splice variant II; shank3 splice variant III; shank3 splice variant IV; Shank3b; SHANK3c-3; SHANK3c-4; shank3e splice variant III; shank3e splice variant IV; somatostatin receptor-interacting protein; Spank1; SPANK-1; SPANK-2; SPANK-3; SSTR-interacting protein; Sstrip; synamon
• Gene Symbols: Shank1, SHANK2, Shank3
• Host Species: Mouse
• Immunogen: Fusion protein amino acids 84-309 of rat Shank2.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 171093, 210274, 22941, 243961, 50944, 58234, 59312, 78957, 85358
• Target Species: Human, Mouse, Rat
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1