Invitrogen™ Pan SHANK Monoclonal Antibody (N23b/49), PE

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545441

Catalog No. PIMA545441

Description

1 μg/mL of MA5-45441 was sufficient for detection of Shank1-4 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 160kDa. Recognizes Shank1, 2 and 3.

Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina. Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease.

Specifications

• Antigen: Pan SHANK
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
• Gene Accession No.: D3YZU1, Q4ACU6, Q80Z38, Q9BYB0, Q9JLU4, Q9QX74, Q9UPX8, Q9WV48, Q9Y566
• Gene Symbols: Shank1, SHANK2, Shank3
• Immunogen: Fusion protein amino acids 84-309 of rat Shank2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry, Microarray
• Clone: N23b/49
• Conjugate: PE
• Gene: SHANK2
• Gene Alias: AI841104; AUTS17; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CORTBP1; CTTNBP1; DEL22q13.3; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; KIAA1022; Kiaa1650; mKIAA1022; proline rich synapse associated protein 1; proline rich synapse associated protein 2; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; Proline-rich synapse-associated protein 2; ProSAP1; Prosap2; PSAP2; SAPAP-interacting protein synamon; SCZD15; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains 3; SH3 and multiple ankyrin repeat domains protein 1; SH3 and multiple ankyrin repeat domains protein 2; SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-3; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-2; SH3/ankyrin domain gene 1; SH3/ankyrin domain gene 2; SH3/ankyrin domain gene 3; SHANK; shank postsynaptic density protein; Shank postsynaptic density protein 3a; SHANK1; Shank1a; Shank2; Shank3; shank3 splice variant II; shank3 splice variant III; shank3 splice variant IV; Shank3b; SHANK3c-3; SHANK3c-4; shank3e splice variant III; shank3e splice variant IV; somatostatin receptor-interacting protein; Spank1; SPANK-1; SPANK-2; SPANK-3; SSTR-interacting protein; Sstrip; synamon
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 171093, 210274, 22941, 243961, 50944, 58234, 59312, 78957, 85358
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov