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Invitrogen™ PANK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552563

Catalog No. PIPA552563


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Description

Description

Immunogen sequence: SLHTVFCATG GGAYKFEQDF LTIGDLQLCK LDELDCLIKG ILYIDSVGFN GRSQCYYFEN PADSEKCQKL PFDLKNPYPL LLVNIGSGVS ILAVYSKDNY KRVTGT Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PANK2
Polyclonal
Unconjugated
PANK2
4933409I19Rik; AI642621; C20orf48; Hallervorden-Spatz syndrome; HARP; hPanK2; HSS; NBIA1; PANK2; pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome); pantothenate kinase 2, mitochondrial; pantothenate kinase 2, mitochondrial isoform 1 preproprotein; pantothenate kinase 2, mitochondrial-like; pantothenic acid kinase 2; PKAN
Rabbit
Antigen Affinity Chromatography
RUO
80025
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
0.1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q9BZ23
PANK2
Recombinant protein corresponding to Human PANK2. Recombinant protein control fragment (Product #RP-89756).
100 μL
Primary
Human
Antibody
IgG
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