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Invitrogen™ PANK2 Polyclonal Antibody
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Catalog No. PIPA5116847
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100 μL
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PIPA5116847 100 μL
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Catalog No. PIPA5116847 Supplier Invitrogen™ Supplier No. PA5116847
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse lung Immunogen sequence: RDKNFSSLHT VFCATGGGAY KFEQDFLTIG DLQLCKLDEL DCLIKGILYI DSVGFNGRSQ CYYFENPADS EKCQKLPFDL KNPYPLLLVN IGSGVSILAV Y.

Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
TRUSTED_SUSTAINABILITY

Specifications

Antigen PANK2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.52 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene PANK2
Gene Accession No. 0
Gene Alias 4933409I19Rik; AI642621; C20orf48; Hallervorden-Spatz syndrome; HARP; hPanK2; HSS; NBIA1; PANK2; pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome); pantothenate kinase 2, mitochondrial; pantothenate kinase 2, mitochondrial isoform 1 preproprotein; pantothenate kinase 2, mitochondrial-like; pantothenic acid kinase 2; PKAN
Gene Symbols PANK2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PANK2 (NP_7059022).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 74450
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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