Invitrogen™ PANK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116847

Catalog No. PIPA5116847

Description

Positive Samples: Mouse lung Immunogen sequence: RDKNFSSLHT VFCATGGGAY KFEQDFLTIG DLQLCKLDEL DCLIKGILYI DSVGFNGRSQ CYYFENPADS EKCQKLPFDL KNPYPLLLVN IGSGVSILAV Y.

Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).

Specifications

• Antigen: PANK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PANK2
• Gene Alias: 4933409I19Rik; AI642621; C20orf48; Hallervorden-Spatz syndrome; HARP; hPanK2; HSS; NBIA1; PANK2; pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome); pantothenate kinase 2, mitochondrial; pantothenate kinase 2, mitochondrial isoform 1 preproprotein; pantothenate kinase 2, mitochondrial-like; pantothenic acid kinase 2; PKAN
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 74450
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.52 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: 0
• Gene Symbols: PANK2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PANK2 (NP_7059022).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG