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PANK2 Mouse anti-Canine, Human, Non-human primate, Rat, Clone: OTI3H9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525152

Catalog No. PIMA525152


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Description

Description

Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
Specifications

Specifications

PANK2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9BZ23
Pantothenate kinase 2, mitochondrial; hPanK2; Pantothenic acid kinase 2; PANK2; C20orf48
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
296167, 477168, 717639, 80025
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI3H9
Unconjugated
PANK2
Liquid
PANK2
Full length human recombit protein of PANK2 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Non-human primate, Rat
Documents
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