Invitrogen™ PAPPA Monoclonal Antibody (PAPP A 1-1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ ABS0060102

Catalog No. ABS0060102

Description

ABS 006-01-02 detects native Pregnancy-associated plasma protein A (PAPP-A) from human samples. ABS 006-01-02 has been successfully used in Western blotting, Immunohistochemistry and ELISA procedures. By Western blot, only unreduced forms of PAPA-A can be detected. In sandwich ELISA with a polyclonal antibody in coat, ABS 006-01-02 only reacts poorly with PAPP-A in third trimester serum. The epitope of ABS 006-01-02 is different from BTE 004-09-02 and ABS 006-24-02. The epitope is located on the PAPP-A subunit of the heterotetramer. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL.

Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterottetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down's syndrome (trisomy 21).

Specifications

• Antigen: PAPPA
• Classification: Monoclonal
• Concentration: 1.10 mg/mL
• Formulation: PBS with 15 mM sodium azide; pH 7.4
• Gene Accession No.: Q13219
• Gene Symbols: PAPPA
• Immunogen: Purified human PAPP-A.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: PAPP A 1-1
• Conjugate: Unconjugated
• Gene: PAPPA
• Gene Alias: 8430414N03Rik; ASBABP2; aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; DIPLA1; IGFBP-4 ase; IGFBP-4ase; IGF-dependent IGFBP-4 protease; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease; PAG1; PAPA; PAPP A; PAPPA; PAPP-A; PAPPA1; Pappalysin; pappalysin 1; pappalysin-1; pregnacy-associated plasma protein A; pregnancy-associated plasma protein A; pregnancy-associated plasma protein A, pappalysin 1; RP11-45A16.1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5069
• Content And Storage: 4°C, store in dark
• Form: Liquid