Invitrogen™ PAPPA2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547179

Catalog No. PIPA547179

Description

In Western blots, less than 1% cross-reactivity with recombinant human PAPP-A is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.

Specifications

• Antigen: PAPPA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PAPPA2
• Gene Alias: LOC680415; PAPPA2; PAPP-A2; pappalysin 2; pappalysin-2; Pappe; PAPP-E; PLAC3; placenta-specific 3; pregnancy-associated plasma preproprotein-A2; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1; pregnancy-associated plasma protein-E; RP4-774I24.1; similar to pappalysin 2 isoform 1
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 60676
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunoprecipitation, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9BXP8
• Gene Symbols: PAPPA2
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Pappalysin-2/PAPP-A2 Ser234-Cys1396.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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