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Invitrogen™ PAPPA2 Polyclonal Antibody
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Catalog No. PIPA547179
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100 μg
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Catalog No. Quantity
PIPA547179 100 μg
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Catalog No. PIPA547179 Supplier Invitrogen™ Supplier No. PA547179
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Description

Goat Polyclonal Antibody

In Western blots, less than 1% cross-reactivity with recombinant human PAPP-A is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PAPPA2
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene PAPPA2
Gene Accession No. Q9BXP8
Gene Alias LOC680415; PAPPA2; PAPP-A2; pappalysin 2; pappalysin-2; Pappe; PAPP-E; PLAC3; placenta-specific 3; pregnancy-associated plasma preproprotein-A2; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1; pregnancy-associated plasma protein-E; RP4-774I24.1; similar to pappalysin 2 isoform 1
Gene Symbols PAPPA2
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human Pappalysin-2/PAPP-A2 Ser234-Cys1396.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60676
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

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